Angiotensin II levels are elevated at peak and trough with once daily dosing of valsartan

Once-daily dosing of gentamicin.

Gentamicin remains one of the most effective and commonly used antimicrobials in the armamentarium of clinicians treating pelvic infections. It continues to reliably cover the aerobic gram-negative rods seen within polymicrobial infections. Available in its generic form, it becomes the low-cost drug of choice in these settings. So why mess with success? As Wiesenfield et al point out in this is...

Comparison of once-daily versus twice-daily dosing of valsartan in patients with chronic stable heart failure

BACKGROUND The safety of once-daily (qd) dosing of valsartan in heart failure (HF) patients is not known. HYPOTHESIS This 10-week, double-blind trial examined the relative safety and efficacy of valsartan administered qd versus twice-daily (bid). METHODS HF patients (NYHA class II-III) receiving diuretics (87%), angiotensin-converting enzyme inhibitors (98%), beta-blockers (92%), aldosteron...

Once-daily dosing of nevirapine in HAART.

Non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens provide simpler and more easily tolerated treatment alternatives to protease inhibitor-based regimens, potentially improving adherence. Long-term viral suppression relies on adherence to a prescribed antiretroviral treatment regimen. Simplification of dosing schedules has prompted investigations into once-daily dosing regimen...

Once-daily-dosing intramuscular gentamicin in neonates.

"Random" gentamicin concentrations do not predict trough levels in neonates receiving once daily fixed dose regimens

BACKGROUND Monitoring plasma gentamicin concentrations in neonates 24 hours after a once daily dose (4 mg/kg) often necessitates additional blood sampling. In adults a nomogram has been developed enabling evaluation of gentamicin doses by sampling concentrations with other blood tests, 4-16 hours after administration. We attempted to develop a similar nomogram for neonates. METHODS In additio...